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Listar por autor "Orta Vázquez, Manuel Luis"
Mostrando ítems 1-17 de 17
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Artículo
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; López Lázaro, Miguel; Cortés, Felipe; Mateos Cordero, Santiago; Helleday, Thomas (Oxford University Press, 2013)5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological ...
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A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; López Lázaro, Miguel (Georg Thieme Verlag, 2013)Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium ...
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Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
Hajji, Nabil; García Revilla, Juan; Sarmiento Soto, Manuel; Perryman, Richard; Symington, Jake J.; Quarles, Chad C.; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; Venero Recio, José Luis; Syed, Nelofer (American Society for Clinical Investigation, 2022)New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the ...
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Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid
Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Guillén Mancina, Emilio; Mateos Cordero, Santiago; López Lázaro, Miguel (MDPI AG, 2016)Epidemiological studies have found a positive association between coffee consumption and a lower risk of cardiovascular ...
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Effect of DNA repair deficiencies on the cytotoxicity of resveratrol
López Lázaro, Miguel; Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago (2015)Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial ...
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Evaluating the cancer therapeutic potential of cardiac glycosides
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Orta Vázquez, Manuel Luis; Maldonado Navas, Dolores; García Domínguez, Irene; López Lázaro, Miguel (Hindawi Publishing Corporation, 2014)Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure ...
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Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
Groth, Petra; Orta Vázquez, Manuel Luis; Elvers, Ingegerd; Majumder, Muntasir Mamun; Lagerqvist, Anne; Helleday, Thomas (Oxford University Press, 2012)Ionizing radiation (IR) produces direct two-ended DNA double-strand breaks (DSBs) primarily repaired by non-homologous end ...
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Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Petermann, Eva; Orta Vázquez, Manuel Luis; Issaeva, Natalia; Schultz, Niklas; Helleday, Thomas (Elsevier, 2010)Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results ...
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In vitro anticancer activity and mechanism of action of an aziridinyl galactopyranoside
Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; Orta Vázquez, Manuel Luis; Jiménez Alonso, Julio José; Palo Nieto, Juan Carlos; Vega Holm, Margarita; Vega Pérez, José Manuel; Iglesias Guerra, Fernando; Mateos Cordero, Santiago; López Lázaro, Miguel; Calderón Montaño, José Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2022)We recently screened a series of new aziridines β-D-galactopyranoside derivatives for selective anticancer activity and ...
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Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation
Rivas Domínguez, Antonio; Mohamed Mohamed, Himan; Jiménez Palomares, Margarita; García Morales, Victoria; Martínez López, Laura; Orta Vázquez, Manuel Luis; Ramos Rodríguez, Juan José; Bermúdez Pulgarín, Beatriz (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Aging continues to be the main cause of the development of Alzheimer’s, although it has been described that certain chronic ...
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RENEB accident simulation exercise
Brzozowska, Beata; Ainsbury, Elizabeth; Baert, Annelot; Beaton Green, Lindsay; Barrios, Leonardo; Barquinero, Joan Francesc; Domínguez García, Inmaculada; Orta Vázquez, Manuel Luis; Wojcik, Andrzej (Taylor & Francis LTD, 2017)Purpose: The RENEB accident exercise was carried out in order to train the RENEB participants in coordinating and managing ...
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Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside
Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; Orta Vázquez, Manuel Luis; Jiménez Alonso, Julio José; Vega Holm, Margarita; Vega Pérez, José Manuel; Iglesias Guerra, Fernando; Mateos Cordero, Santiago; López Lázaro, Miguel; Calderón Montaño, José Manuel (Wiley, 2018)Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability ...
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The Cockayne syndrome protein B is involved in the repair of 5-AZA-2′-deoxycytidine-induced DNA lesions
Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Pastor Carrillo, Nuria María; Ruiz Castizo, Ángel; Domínguez García, Inmaculada; López Lázaro, Miguel; Mateos Cordero, Santiago; Orta Vázquez, Manuel Luis (Impact Journals, 2018)The Cockayne Syndrome Protein B (CSB) plays an essential role in Transcription-Coupled Nucleotide Excision Repair (TC-NER) ...
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Artículo
The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; López Lázaro, Miguel; Helleday, Thomas (Oxford University Press, 2014)Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid ...
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The Role of DNA Damage Response in Dysbiosis-Induced Colorectal Cancer
Rivas Domínguez, Antonio; Pastor Carrillo, Nuria María; Martínez López, Laura; Colón Pérez, Julia; Bermúdez Pulgarín, Beatriz; Orta Vázquez, Manuel Luis (Multidisciplinary Digital Publishing Institute (MDPI), 2021)The high incidence of colorectal cancer (CRC) in developed countries indicates a predominant role of the environment as a ...
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Trabajo Fin de Grado
El uso de las TIC mediante el aprendizaje cooperativo : atendiendo a la diversidad en Educación Primaria
Marín Bernal, Sonia (2015)Como educadores la primera cuestión que debemos plantearnos es qué es la Educación. Podemos definirla como la acción que ...
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Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
Orta Vázquez, Manuel Luis; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; Domínguez García, Inmaculada; Calderón Montaño, José Manuel; Huertas Castaño, Carlos; López Lázaro, Miguel; Helleday, Thomas; Mateos Cordero, Santiago (Elsevier, 2017)Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that ...